تأثیر هشت هفته تمرین هوازی بر مقادیر پلاسمایی آنزیم پاراکسوناز-1 و لیپید هیدروپراکسید در موش‌های نر دیابتی شده تحت تیمار با جلبک کلرلا

    Background and Objectives: Aerobic exercise and taking chlorella supplementation to control oxidative stress markers and paraoxonase-1 (PON1) levels in diabetic patients is of great importance. So, the aim of the present research was to investigate the effect of eight-week aerobic exercise on paraoxonase-1 and lipid hydroperoxide plasma levels in diabetic Wistar rats treated with chlorella algae. Material and Methods: The present study was an experimental research. 50 male Wistar rats were randomly divided into 5 groups of 10: control, diabetic, diabetic with taking supplement (colorella), diabetic with training, and combined diabetic (training+ supplement) groups. Training and taking supplement continued for 8 weeks after diabetes induction; at the end of the 8th week, the levels of paraoxonase-1 and lipid hydroperoxide were measured. Data were analyzed using one-way ANOVA and Tukey’s post hoc test. Results: The results showed that there were significant differences between the groups in terms of paraoxonase-1(p=0.001). Comparison between the groups of chlorella and training (p=0.001) and the combined and chlorella (p=0.001) as well as the exercise and combined (p=0.007) showed a significant difference. Also, there were significant differences between the groups in terms of lipid hydroperoxide (p=0.001). So that there was a significant difference between the training and chlorella (p=0.005) and combined groups (p=0.001) and the combined and exercise groups (p=0.029). So that in the combined group, paraoxonase -1 was further increased. Conclusion: Eight weeks of aerobic training along with taking chlorella can remarkably reduce lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes; However, their separate protocls can be also useful. Key words: Diabetes, Aerobic exercise, Algae chlorella, Paraoxonase-1, Lipid hydroperoxide, Rat   Funding: This study was funded by Islamic Azad University, Tabriz Branch. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Islamic Azad University, Tabriz Branch approved the study.     How to cite this article: Khanzadeh N, Poozesh Jadidi R, Nour Azar MA. The Effect of Eight Weeks of Aerobic Exercise on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats Treated with Chlorella Algae. Univ Med Sci 2018; 17 (2): 131-42 [Farsi]